Table 3.
List of catalytic dyad and conserved amino acids of SARS-CoV and SARS-CoV-2 Mpro interacting with various inhibitors.
| Catalytic dyad & Conserved amino acids of Mpro | SARS-CoV-2 Mpro |
SARS-CoV Mpro |
||||||
|---|---|---|---|---|---|---|---|---|
| TMB607 | TMC 310911 | Lopinavir (Bolcato et al., 2020) | Ritonavir (Bolcato et al., 2020) | Nelfinavir (Bolcato et al., 2020) | Isatin derivatives |
|||
| Compound 5f (Zhou et al., 2006) | Compound 4k (Chen et al., 2005) | Compound 4o (Chen et al., 2005) | ||||||
| His41 | His41 | – | His41 | His41 | His41 | His41 | His41 | His41 |
| Cys145 | Cys145 | – | – | Cys145 | Cys145 | Cys145 | Cys145 | Cys145 |
| Leu27 | – | – | – | – | – | – | – | – |
| Tyr53 | – | – | – | – | – | – | – | – |
| Phe139 | – | – | – | – | – | – | – | – |
| Gly142 | – | – | – | – | – | – | – | – |
| His163 | His163 | – | – | – | – | His163 | – | – |
| Glu166 | Glu166 | Glu166 | Glu166 | Glu166 | Glu166 | Glu166 | – | – |
| Leu167 | Leu167 | – | Leu167 | – | – | – | – | – |
| His172 | His172 | – | – | – | – | His172 | – | – |
| Asp187 | – | – | Asp187 | – | – | – | – | – |
| Gln192 | Gln192 | – | – | – | – | – | – | – |