Table 1: Depression randomized clinical trial:

Description of the p = 9 baseline covariates (means and SDs); the estimated values (“Indiv. Value”) of treatment decision rules from each individual covariate, using either the B-spline regression (“Nonpar.”, in the third column) or the linear regression (“Linear”, in the fourth column); the estimated single-index coefficients (in the last three columns), and the values of the associated treatment decision rules from the three methods (in the bottom row).

(Label) Baseline	Mean	Indiv. Value		Coefficients αj’s, j ∈ {1, …, 9}
patient characteristics	(SD)	Nonpar.	Linear	SIMML*	SIMML	linGEM
(xi) Age at evaluation	38.00 (13.84)	8.56	8.24	−0.53	−0.50	−0.43
(x2) Severity of depression	18.80 (4.29)	6.85	7.07	−0.07	−0.13	−0.37
(х3) Dur. MDD (month)	38.19 (53.17)	7.42	7.33	0.08	−0.18	0.20
(x4) Age at MDD	16.46 (6.09)	6.29	6.95	0.23	0.05	0.31
(x5) Axis II	3.92 (1.43)	7.16	7.11	0.23	0.20	0.17
(x6) Word Fluency	37.42 (11.68)	7.64	7.11	0.11	0.09	0.27
(x7) Flanker RT	59.51 (26.63)	8.19	8.39	0.12	0.23	−0.18
(x8) Post-conflict adjus.	0.07 (0.12)	6.73	7.23	−0.30	−0.29	−0.18
(x9) Flanker Accuracy	0.22 (0.15)	7.89	8.37	0.70	0.70	0.59
Value from single-index model				9.34	8.72	8.22