Skip to main content
. Author manuscript; available in PMC: 2020 Aug 21.
Published in final edited form as: Trends Biochem Sci. 2017 Feb 7;42(4):312–325. doi: 10.1016/j.tibs.2017.01.003
Problem with CII Pathology Manifestation Refs
SDHA-D PHEO/PGL Hypertention, palpitation, sweating [99]
SDHA-D GIST Abdominal pain, gastrointestinal bleeding [91, 100]
SDHA-D Renal cell carcinoma Hematuria, abdominal pain [101–103]
SDHA-D Carney triad Similar to PHEO/PGL and GIST [104]
SDHA-D Carney dyad (Carney–Stratakis syndrome) Similar to PHEO/PGL and GIST [105,106]
SDHAF2 PHEO/PLG, preferentially head and neck PGL mainly in young adults Similar to PHEO/PGL [107,108]
SDHB Pancreatic NET Abdominal pain [109]
SDHB Ganglioneuroma Abdominal pain [109]
SDHA-D PHEO/PGL and pituitary adenoma (3PAs) Similar to PHEO/PGL; headache, visual problems, clinical characteristics related to hypersecretion of GH and PRL [110–112]