Table 2.
Descriptive statistics of standard coagulation parameters, thromboelastometry, platelet function analysis, and DIC score (median and IQR).
| Normal range | COVID-19 | Non-COVID-19 | |
|---|---|---|---|
| Platelets [G/l] | 146–391 | 227 (175, 324) | 175 (113, 347) |
| VWF activity [%] | 48–148 | 226 (204, 312) | NA |
| VWF antigen [%] | 53–154 | 300 (249, 371) | NA |
| aPTT [sec] | 22–34 | 29 (26, 32) | 29 (26, 42) |
| INR⁎ | 0.8–1.2 | 1.00 (0.96, 1.01) | 1.12 (1.06, 1.31) |
| Fibrinogen [mg/dl] | 210–400 | 709 (530, 786) | 598 (502, 645) |
| Antithrombin [%]⁎ | 75–130 | 89 (82, 104) | 65 (49, 75) |
| D-dimer [mg/l]⁎ | ≤0.5 | 2.4 (2.0, 3.9) | 11.3 (4.1, 31.0) |
| EXTEM® CT [sec] | 38–79 | 62 (56, 68) | 70 (58, 78) |
| EXTEM® CFT [sec] | 34–159 | 93 (55, 97) | 84 (80, 113) |
| EXTEM® Time to twenty⁎ | 143 (119, 151) | 155 (140, 177) | |
| EXTEM® MCF [mm] | 50–72 | 65 (63, 70) | 66 (53, 72) |
| EXTEM® ML [%] | ≤15 | 6.5 (4.5, 9.0) | 5.0 (2.3, 7.0) |
| FIBTEM® MCF [mm]⁎ | 9–25 | 29 (24, 34) | 22 (18, 24) |
| DIC score⁎ | 1 (1, 1) | 3 (1, 4) |
NA not available, VWF von-Willebrand-Factor, aPTT activated partial thromboplastin time, INR international normalized ratio, D-dimer in fibrinogen equivalent units (FEU), CT clotting time, CFT clot formation time, MCF maximal clot firmness, ML maximum lysis, DIC Disseminated Intravascular Coagulation.
⁎
p < 0.05.