Table 4.

Recommendations for approaches to future basic, translational, and clinical studies (Bernhardt et al., 2017; Corbett et al., 2017; Kwakkel et al., 2017).

Overall Goals

Trial Considerations

Understand natural history of recovery Collect neurobiological data in humans Characterize stroke recovery phenotypes Organize network of clinical centers Align preclinical and clinical studies:  Appropriate animal models, tissue and behavioral outcomes Train new neural repair and stroke recovery researchers

Use standard definitions of recovery Include patient characteristics:  Demographics, medical history, location/size of stroke, responders vs nonresponders Include time points post stroke:  Enroll within 7 days and include outcomes at least 3 months post stroke Include time points post stroke:  NIHSS (stroke severity), FM (function and structure), ARAT (upper limb), EQ-5D (quality of life), mRS (global disability)