Table 1.
Approved Buprenorphine Products
| Formulations | FDA approval year | Available doses (mg) | Total cost per montha | Dissolution time (min) |
|---|---|---|---|---|
| Buprenorphine/Naloxone Tablet | 2002 for brand name productsb | 2/0.5 and 2 | $154 | 7 – 12.4 |
| 2013 and after for generics | 8/2 and 8 | $164 | ||
| Buprenorphine/Naloxone Film | 2010 | 2/0.5 | $131 | 5 – 6.6 |
| 4/1 | $222 | |||
| 8/2 | $222 | |||
| 12/3 | $432 | |||
| Buprenorphine/Naloxone Tablet (Zubsolv®) | 2013 | 0.7/0.18 | $131 | 5 |
| 1.4/0.36 | $131 | |||
| 2.9/0.71 | $254 | |||
| 5.7/1.4 | $254 | |||
| 8.6/2.1 | $377 | |||
| 11.4/2.9 | $499 | |||
| Buprenorphine/Naloxone Film (Bunavail®) | 2014 | 2.1/0.3 | $252 | 30 |
| 4.2/0.7 | $252 | |||
| 6.3/1.0 | $495 | |||
| 6-month Buprenorphine Implant (Probuphine®) | 2016 | 320 | $825 | N/A |
| Monthly Buprenorphine Depot(Sublocade®) | 2017 | 100 | $1,580 | N/A |
| 300 | $1,580 | |||
N/A not applicable
a
Total cost for transmucosal products is assuming once daily use for 30 days. Total cost for the 6-month product is $4,950. Prices taken from drugs.com on February 1, 2018.
b
The brand name mono-product tablet was no longer marketed after 2011, but the generic mono-product remains available and is still used for patients with naloxone sensitivities and for pregnant women. The brand name combination product is also no longer available.