Fig. 3.

Molecular imaging and theranostic approaches in pheochromocvtoma and paraganglioma

Metastatic SDHB-related PPGL. Previous history of surgery for PHEOs and extradrenal PGLs. The anterior maximum intensity projection images of ⁶⁸Ga-DOTATATE (a), ¹⁸F–FDG (b), ¹⁸F–FDA (c), and ¹⁸F–FDOPA (d) demonstrates ⁶⁸Ga-DOTATATE and ¹⁸F–FDG identifies similar number of lesions and perform superior than ¹⁸F–FDA and ¹⁸F–FDOPA. The right adrenal recurrent pheochromocytoma (marked by green arrows) is missed on ¹⁸F–FDOPA but identified by other radiotracers. All the scans identify liver lesion in dome of right lobe (red arrows), intensity is low in ¹⁸F–FDA, whereas the liver lesion located in inferior right lobe of liver (black arrows) is missed on ¹⁸F–FDA. The localization of skeletal metastases is similar on ⁶⁸Ga-DOTATATE, ¹⁸F–FDG, and ¹⁸F–FDA whereas it is suboptimal on ¹⁸F–FDOPA