Table 4.

Nuclear transcript levels of opioid genes in the nucleus accumbens shell were altered after chronic (4-week) excessive alcohol drinking (FDR < 0.05). FC, fold change; FDR, false discovery rate; average DESeq2 normalized count (NC) for water and alcohol -exposed mice (n=6 samples for each group).

Gene	Fold	p-Value	FDR	Water NC	Alcohol NC	Name
Pomc	1.32	9.10E-04	0.023	75	175	Proopiomelanocortin
Oprm1	0.92	0.284	0.508	404	373	Mu opioid receptor
Pdyn	0.93	0.351	0.574	2388	2192	Prodynorphin
Oprk1	0.95	0.485	0.688	757	720	Kappa opioid receptor
Penk	1.08	0.330	0.555	9684	10756	Proenkephalin
Oprd1	1.15	0.077	0.245	259	319	Delta opioid receptor
Pnoc	1.07	0.401	0.616	43	52	Pronociceptin
Oprl1	0.98	0.877	0.942	765	753	Nociceptin receptor