Table 5.
Nuclear transcript levels of mTORC2 pathway and related genes in the nucleus accumbens shell were altered after chronic (4-week) excessive alcohol drinking (FDR < 0.05). FC, fold change; FDR, false discovery rate; average DESeq2 normalized count (NC) for water and alcohol -exposed mice (n=6 samples for each group).
| Gene | Fold | p-Value | FDR | Water NC | Alcohol NC | Name |
|---|---|---|---|---|---|---|
| Sgk1 | 1.36 | 3.75E-08 | 3.11E-05 | 1216 | 1727 | serum/glucocorticoid regulated kinase 1 |
| Acta1 | 1.24 | 0.012 | 0.089 | 35 | 48 | actin alpha 1 |
| Acta2 | 1.03 | 0.703 | 0.703 | 22 | 24 | actin alpha 2 |
| Actb | 1.09 | 0.058 | 0.212 | 18222 | 19925 | actin beta |
| Actbl2 | 1.01 | 0.755 | 0.755 | 0.64 | 0.80 | actin beta like 2 |
| Actc1 | 1.00 | 0.788 | 0.788 | 0.140 | 0.147 | actin alpha cardiac muscle 1 |
| Actg1 | 1.09 | 0.046 | 0.187 | 980 | 1084 | actin gamma 1 |
| Actg2 | 1.00 | 0.892 | 0.893 | 0.572 | 0.354 | actin gamma 2 |
| Actl6a | 1.00 | 0.990 | 0.996 | 227 | 227 | actin-like protein 6A |
| Actl6b | 1.05 | 0.391 | 0.608 | 562 | 595 | actin-like protein 6B |
| Actl7b | 0.99 | 0.864 | 0.864 | 0.925 | 0.596 | actin-like protein 7A |
| Actl10 | 1.03 | 0.238 | 0.238 | 0.120 | 0.639 | actin-like protein 10 |
| Actr1a | 1.00 | 0.912 | 0.960 | 2418 | 2426 | actin related protein 1A |
| Actr1b | 1.08 | 0.133 | 0.335 | 1537 | 1677 | actin related protein 1B |
| Actr2 | 1.10 | 0.092 | 0.274 | 4607 | 5129 | actin related protein 2 |
| Actr3 | 1.13 | 0.014 | 0.100 | 1875 | 2141 | actin related protein 3 |
| Actr3b | 1.02 | 0.687 | 0.831 | 924 | 943 | actin related protein 3B |
| Actr5 | 0.99 | 0.793 | 0.896 | 162 | 164 | actin related protein 5 |
| Actr6 | 1.07 | 0.146 | 0.351 | 310 | 336 | actin related protein 6 |
| Actr8 | 1.03 | 0.493 | 0.696 | 778 | 797 | actin related protein 8 |
| Actr10 | 1.03 | 0.341 | 0.565 | 1480 | 1534 | actin related protein 10 |
| Actrt3 | 1.04 | 0.674 | 0.674 | 10 | 13 | actin related protein T3 |
| Akt1 | 1.10 | 0.040 | 0.403 | 1165 | 1278 | serine/threonine-protein kinase, RAC-alpha |
| Akt1s1 | 1.09 | 0.101 | 0.301 | 231 | 251 | proline-rich AKT1 substrate 1 |
| Akt2 | 1.22 | 0.006 | 0.059 | 730 | 890 | serine/threonine-protein kinase, RAC-beta |
| Akt3 | 1.20 | 0.055 | 0.168 | 3807 | 4555 | serine/threonine-protein kinase, RAC-gamma |
| Aktip | 1.01 | 0.919 | 0.942 | 1690 | 1703 | AKT-interacting protein |
| Fyn | 1.04 | 0.381 | 0.599 | 989 | 1032 | proto-oncogene tyrosine-protein kinase |
| Gsk3a | 1.17 | 0.005 | 0.059 | 663 | 795 | glycogen synthase kinase 3 alpha |
| Gsk3b | 1.12 | 0.084 | 0.261 | 3903 | 4486 | glycogen synthase kinase 3 beta |
| Gskip | 1.06 | 0.140 | 0.345 | 473 | 504 | glycogen synthase kinase 3 beta interacting protein |
| Prkca | 1.17 | 0.035 | 0.161 | 2450 | 2996 | protein kinase C alpha |
| Prkcb | 1.24 | 0.005 | 0.058 | 7773 | 10352 | protein kinase C beta |
| Prkcd | 1.20 | 0.025 | 0.134 | 213 | 416 | protein kinase C delta |
| Prkcdbp | 0.96 | 0.528 | 0.722 | 134 | 124 | protein kinase C delta binding protein |
| Prkce | 1.20 | 0.014 | 0.096 | 3809 | 4783 | protein kinase C epsilon |
| Prkcg | 1.16 | 0.067 | 0.227 | 1159 | 1428 | protein kinase C gamma |
| Prkch | 1.04 | 0.641 | 0.803 | 836 | 885 | protein kinase C eta |
| Prkci | 1.15 | 0.038 | 0.168 | 852 | 1007 | protein kinase C iota |
| Prkcq | 1.15 | 0.023 | 0.129 | 164 | 202 | protein kinase C theta |
| Prkcz | 1.10 | 0.073 | 0.238 | 2418 | 2685 | protein kinase C zeta |
| Rac1 | 1.10 | 0.023 | 0.130 | 2413 | 2684 | ras-related C3 botulinum toxin substrate 1 |
| Rac2 | 1.18 | 0.064 | 0.645 | 16 | 21 | ras-related C3 botulinum toxin substrate 2 |
| Rac3 | 1.02 | 0.735 | 0.860 | 83 | 86 | ras-related C3 botulinum toxin substrate 3 |
| Rictor | 1.03 | 0.491 | 0.694 | 2374 | 2440 | rapamycin-insensitive companion of mTOR |
| Sgk2 | 0.84 | 0.048 | 0.480 | 27 | 18 | serum/glucocorticoid regulated kinase 2 |
| Sgk3 | 0.98 | 0.752 | 0.871 | 654 | 642 | serum/glucocorticoid regulated kinase 3 |
| Tiam1 | 1.12 | 0.079 | 0.250 | 2298 | 2616 | T-lymphoma invasion and metastasis-inducing protein 1 |
| Tiam2 | 1.11 | 0.108 | 0.296 | 1499 | 1701 | T-lymphoma invasion and metastasis-inducing protein 2 |