Table 2.

Observer performance study by Cole et al.[38] comparing single reading with and without CAD using two commercial CAD systems and 300 screening mammography cases (150 cancer and 150 benign or normal) from DMIST. None of the changes were statistically significant. AUC=area under the receiver operating characteristic curve. N=number of radiologists in the study.

	CAD system A		CAD system B
Standalone performance	75% sensitivity at 0.79 FPs/image		73% sensitivity at 0.77 FPs/image
Radiologists	N=14		N=15
	Without CAD	With CAD	Without CAD	With CAD
Average AUC	0.71	0.72	0.71	0.72
Average sensitivity	49%	51%	51%	53%
Average specificity	89%	87%	87%	86%