Table 5.

Influence of Treatment and Nutrition Parameters on Age at Puberty and Bone Age Discrepancy

Predictor (Parameter)	Regression Coefficient (95% CI); pa
	Age at Pubertyb		∆ Bone Age at Pubertyb
	β ± SE (95% CI)	P	β ± SE (95% CI)	P
Treatment
Age at RT, y	0.323 ± 0.144 (0.017, 0.628)	0.04	−0.357 ± 0.160 (−0.697, −0.017)	0.04
Hypothalamic RT dose, Gy	0.055 ± 0.030 (−0.009, 0.119)	0.09	−0.036 ± 0.036 (−0.111, 0.040)	0.3
Nutrition
Malnutrition duration, mo	0.090 ± 0.064 (−0.044, 0.225)	0.2	−0.082 ± 0.072 (−0.235, 0.070)	0.3
BMI SDS diagnosis	−0.220 ± 0.224 (−0.695, 0.255)	0.3	−0.036 ± 0.256 (−0.579, 0.507)	0.9
BMI SDS nadir	−0.254 ± 0.202 (−0.682, 0.174)	0.2	0.177 ± 0.231 (−0.313, 0.667)	0.5
∆BMI SDS nadir	−0.182 ± 0.341 (−0.905, 0.542)	0.6	0.548 ± 0.357 (−0.209, 1.305)	0.1
BMI SDS T2	−0.603 ± 0.167 (−0.956, −0.249)	0.002	0.693 ± 0.180 (0.313, 1.074)	0.001
∆BMI SDS T2	−0.394 ± 0.230 (−0.882, 0.095)	0.1	0.615 ± 0.232 (0.123, 1.107)	0.02

Abbreviations: BMI, body mass index; ∆BMI SDS nadir, difference in BMI SDS between nadir and diagnosis; ∆BMI SDS T2, difference in BMI SDS between T2 and nadir; ∆ Bone age, difference between bone age and chronological age; CI, confidence interval; Gy, gray; mo, months; RT, radiation therapy; SDS, standard deviation score; SE, standard error; T2, Tanner stage 2/pubertal onset; .

p* tests hypothesis of no association (zero regression coefficient).

^a Bivariate regression, unadjusted (indicated predictor only).

^b units = year of age or bone-age discrepancy per unit of row variable.