Table 1.
Recent natural product drug introductions, 2008-2018.
| Year | Drug name | Company | Indication | NP template |
|---|---|---|---|---|
| 2008 | Biolimus stent | Biosensors | Stenosis | Rapamycin |
| Ceftobiprole medocaril | Roche | Antibacterial | Cephalosporin | |
| Methyl naltrexone bromide | Wyeth/Progenis | Constipation | Morphinan | |
| 2009 | Nalfurafine HCl | Toray | Pruritis | Morphinan |
| Tebipenem pivoxil | Spero | Antibacterial | Thienamycin | |
| Televancin | Theravance | Antibacterial | Vancomycin | |
| 2010 | Cabazitaxel | Sanofi-Aventis | Cancer | Taxane |
| Ceftaroline fosamil | Takeda | Antibacterial | Cephalosporin | |
| Eribulin mesylate | Eisai | Cancer | Halichondrin | |
| Fingolimod | Novartis | Multiple sclerosis | Myricocin | |
| Mifamurtide | Takeda | Cancer | Muramyl dipeptide | |
| Romidepsin | Fujisawa/Astellas | Cancer | Cyclopeptide | |
| Vinflunine ditartate | Pierre Fabre | Cancer | Vinca alkaloid | |
| Zucapsaicin | E Merck AG | Topical analgesic | Capsaicin | |
| 2011 | Fidaxomicin | Optimer | Antibacterial | Macrolide |
| Spinosad | ParaPro | Antiparasitic | Spinosyn A | |
| 2012 | Arterolane | Ranbaxy | Antiparasitic | Artemisinin |
| Carfilzomib | Proteolix.Onyx | Cancer | Peptide | |
| Crofelemer | Salix/Shaman | Diarrhea | Oligomeric proanthocyanin | |
| Dapagliflozin | Astra Zeneca | Diabetes | Phlorizin | |
| Ingenol mebutate | Peplin/Leo | Cancer | Phorbol ester | |
| Novolimus | Elixir | Stenosis | Rapamycin | |
| Omacetaxine mepsuccinate | ChemGenex/ Teva | Cancer | Homoharringtonine | |
| Pixanthone dimaleate | Cell Therapeutics | Cancer | Anthracycline | |
| 2013 | Canagliflozin | Jannsen | Diabetes | Phlorizin |
| 2014 | --- | |||
| 2015 | Ceftolozame | Astellas/Cubist | Antibacterial | Cephalosporin |
| Dalbavancin | Vicuron/Durata | Antibacterial | Vancomycin | |
| Empagliflozin | Boehringer/Lilly | Diabetes | Phlorizin | |
| Nalogexol | Nektar/Astra Zeneca | Consitpation | Morphinan | |
| Oritavancin | Lilly/Medicines Co. | Antibacterial | Vancomycin | |
| Tofoglozin | Chugai/Sanofi/Kowa | Diabetes | Phlorizin | |
| 2016 | --- | |||
| 2017 | --- | |||
| 2018 | Midostaurin | Novartis | Cancer | Staurosporine |
| Naldimedine | Shionagi | Constipation | Morphinan |