TABLE 2.

Comparison of the response of infant 25(OH)D to intervention or control doses of vitamin D for trials considered eligible for inclusion in the meta-analysis¹

			Baseline			Postsupplementation T1			Postsupplementation T2
Reference	Total n randomized	Dose (IU)	n	25(OH)D (nmol/L)	Infant age	n	25(OH)D (nmol/L)	Infant age	n	25(OH)D (nmol/L)	Infant age
	Maternal vs. infant supplementation
Chandy et al. (33)	74	120,000/m	NR			51	60.8 ± 29.0	3.5 mo		N/A
	78	Control				47	61.3 ± 25.2			N/A
Hollis et al. (34)	165	6400/d2	106	37.9 ± 23.3	4–6 wk	74	106.9 ± 35.1	4 mo	48	108.5 ± 38	7 mo
	169	Control	110	33.7 ± 23.5		74	109 ± 48		47	109.1 ± 31.8
Rothberg et al. (35)	403	1000/d	403	22.2 ± 17.73	Birth	9	23.5 ± 5.2	6 wk		N/A
		500/d				9	25.5 ± 13.7			N/A
		Placebo				10	2.7 ± 3.5			N/A
		Control				12	37.9 ± 9.2			N/A
	Infant bolus vs. daily supplementation
Huynh et al. (36)	34	50,000	29	33 ± 19.3	Within 48 h of birth	31	154 ± 65.3	10 d	26	65 ± 15.6	4 mo
	36	Control	33	32 ± 13.6		31	48 ± 17.0		23	81 ± 9.8
Shakiba et al. (37)	30	50,000 every 2 mo	NR			30	134.0 ± 48.7	4 mo		N/A
	45	Control				26	95.8 ± 28.5			N/A

¹Values are means ± SDs unless otherwise noted. Control is defined as infants receiving 400 IU/d. N/A, not applicable. NR, not reported; T1, first follow-up time point; T2, second follow-up time point; 25(OH)D, 25-hydroxyvitamin D.

²6400 IU/d provided as 6000 IU + 400 IU from prenatal supplement.

³Baseline data not reported separately by group.