Fig. 1.
Identification of 10580 as a candidate compound for GIC/GICR eradication.
(A) Summary of chemical screening. (B) E3R cell viability plots for 10 560 compounds; 319 compounds that cell viability to less than 20% were entered into the second screen. (C) The cytotoxicity of 319 compounds against E3 (gray column, upper panel), E3R (black column, upper panel), E6 (gray column, lower panel), and E6R (black column, lower panel). Then, 302 compounds that decreased both GIC and GICR viability to less than 50% were included in the third screen. (D) The cytotoxicity of 302 compounds against NSCs (black column) and astrocytes (gray column); 9700 (dashed arrow) and 10607 (solid arrow) were selected as candidate compounds by their GI50 effects against GICs/GICRs and structural analysis.