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. 2019 Sep 30;23(1):53–65. doi: 10.1093/ijnp/pyz051

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© The Author(s) 2019. Published by Oxford University Press on behalf of CINP.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 3. — Effect of MCHR1 germline deletion on locomotor activity, stereotypy, marble burying, and social interaction. (A) Distance mice travelled in 60 minutes of locomotion test: male: t = 3.28, P = .005 (n = 9 and 7 for wild type and MCHR1 KO, respectively), female: t = 2.95, P = .011. Unpaired student t test: WT vs MCHR1 KO, *P < .05, **P < .01 (n = 8 and 7 for wild-type and MCHR1 KO, respectively). (B) Stereotypic counts in 60 minutes of locomotion test: male: t = 6.858, P = .0001 (n = 9 and 7 for wild-type and MCHR1 KO, respectively), female: t = 2.96, P < = .011. Unpaired student t test: wild type vs MCHR1 KO,*P < .05, ***P < .001 (n = 8 and 7 for wild type and MCHR1 KO, respectively). (C) Number of marbles buried in 30 minutes: male: t = 5.41, P < .001, female: t = 0.0, P = 1.00. Unpaired student t test wild type vs MCHR1 KO, ***P < .001 (n = 8). (D) Male: Time mice spent interacting with empty cup and control mice in social interaction test: 2-way ANOVA, genotype effect: F_1,38 = 0.21, P = .65, genotype effect × cup interaction F_1,38 = 6.783, P = .01. Bonferroni post hoc test: empty cup vs unfamiliar mouse, wild type: t = 4.08, P < .001, KO: t = 0.51, P > .05.***P < .001 (n = 10 and 11 for wild type and MCHR1 KO, respectively). (E) Female: Time mice spent interacting with empty cup and control mice in social interaction test: 2-way ANOVA, genotype effect: F_1,46 = 0.6378, P = .43, genotype effect × cup interaction: F_1,46 = 5.2, P = .027. Bonferroni post hoc test: empty cup vs unfamiliar mouse, wild type: t = 2.387, P < .01, KO: t = 1.72, P > .05. **P < .01 (n = 13 and 12 for wild type and MCHR1 KO, respectively).