Table 2.
The analysis of MCHR1 in the combined dataset (901 total subjects, each group shown in Table 1 for SZ and controls) showed a significant increase in age in control subjects and increased PMI in subjects with SZ
| Brainbank | Diagnosis | N | M | F | Age_mean | Age_sd | RIN_mean | RIN_sd | PMI_mean | PMI_sd |
|---|---|---|---|---|---|---|---|---|---|---|
| PEC BSHRI | Control | 184 | 108 | 76 | 83.05 | 7.80 | 6.96 | 0.93 | 3.03 | 1.86 |
| PEC SMRI Array | Control | 34 | 25 | 9 | 43.82 | 7.35 | 8.08 | 0.50 | 29.47 | 13.05 |
| PEC SMRI Array | SCZ | 34 | 26 | 8 | 42.53 | 8.59 | 7.99 | 0.62 | 31.56 | 15.74 |
| PEC SMRI Consortium | Control | 13 | 8 | 5 | 49.62 | 10.56 | 7.62 | 0.94 | 23.46 | 8.93 |
| PEC SMRI Consortium | SCZ | 11 | 8 | 3 | 41.82 | 12.46 | 7.25 | 0.70 | 38.36 | 13.95 |
| PEC SMRI Extra | Control | 9 | 8 | 1 | 45.78 | 14.81 | 7.00 | 0.66 | 27.67 | 14.19 |
| PEC SMRI Extra | SCZ | 31 | 23 | 8 | 40.84 | 12.02 | 7.09 | 0.75 | 46.42 | 31.46 |
| PEC SMRI New | Control | 19 | 19 | 0 | 51.42 | 8.69 | 8.16 | 0.62 | 30.11 | 18.38 |
| PEC SMRI New | SCZ | 18 | 10 | 8 | 46.00 | 8.92 | 7.66 | 0.80 | 46.39 | 35.25 |
| CMC MSSM | Control | 164 | 85 | 79 | 73.20 | 16.28 | 7.52 | 0.86 | 10.87 | 7.58 |
| CMC MSSM | SCZ | 148 | 101 | 47 | 72.38 | 12.45 | 7.13 | 0.80 | 23.79 | 15.57 |
| CMC Penn | Control | 37 | 18 | 19 | 67.14 | 15.04 | 7.46 | 0.70 | 13.42 | 7.51 |
| CMC Penn | SCZ | 58 | 23 | 35 | 78.74 | 11.05 | 7.35 | 0.77 | 13.57 | 7.66 |
| CMC Pitt | Control | 84 | 60 | 24 | 48.19 | 14.06 | 8.52 | 0.45 | 18.97 | 5.38 |
| CMC Pitt | SCZ | 57 | 44 | 13 | 48.11 | 13.03 | 8.17 | 0.63 | 20.04 | 8.42 |
| Total | Control | 544 | 331 | 213 | 68.64 | 19.09 | 7.53 | 0.97 | 12.06 | 11.22 |
| Total | SCZ | 357 | 235 | 122 | 61.68 | 18.96 | 7.44 | 0.85 | 25.82 | 19.74 |
| Total | 901 | 566 | 335 | P < .0001 | P = .153 | P < .0001 |
CMC, Common Mind Consortium; PEC, PsychENCODE Consortium; SMRI, Stanley Medical Research Institute; BSHRI, Banner Sun Health Research Institute.
Details on those collections can be found here: https://www.synapse.org/#!Synapse:syn4590909