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. 2019 Oct 21;22(3):333–344. doi: 10.1093/neuonc/noz204

Fig. 5.

Fig. 5

ICOSLG was highly expressed in CD44-high GBMs and predicted poor prognosis. (A) Analysis of TCGA database indicated an inverse correlation between ICOSLG mRNA expression and survival of GBM patients (P = 0.0439, log-rank test, ICOSLG upregulated [solid line] Z-score >1.0, n = 29 vs ICOSLG downregulated [broken line] Z-score <1.0, n = 42). (B) Kaplan–Meier analyses were used to evaluate the correlation between ICOSLG protein expression and survival of 20 newly diagnosed GBM patients (ICOSLG high vs low, P = 0.01, log-rank test). (C) Representative IHC images show the expression of ICOSLG in nontumor brain samples and GBM tissues (n = 2 per group). Scale bars, 50 μm. (D) Representative IHC images of ICOSLG, CD44, and OLIG2 expression in human GBM samples are shown. Scale bars, 50 μm. The tables show the number of patient samples that were classified according to the expression level of ICOSLG, CD44, and OLIG2. ICOSLG was positively correlated with CD44 but inversely correlated with OLIG2. (E) The expression level of mRNA with RNAseq from GBM patient samples (n = 206; TCGA Research Network). Pearson correlation of the expression between ICOSLG and CD44 is shown. Data were visualized using cBioportal.