Table 2.

Multivariable analysis excluding ECM

PFS	EGFR/ALK+ NSCLC	P	Wild Type	P
	HR (95% CI)		HR (95% CI)
Age (<50 vs 50–60 vs >60)	0.83 (0.60, 1.14)	0.24	0.91 (0.73, 1.14)	0.42
KPS (<70 vs 70–80 vs >80)	0.65 (0.43, 1.00)	0.05	0.73 (0.59, 0.92)	0.006
Brain mets (1 vs 2–3 vs >3)	0.92 (0.69, 1.22)	0.56	1.22 (1.02, 1.46)	0.029
Symptomatic	1.11 (0.64, 1.92)	0.71	1.05 (0.74, 1.49)	0.80
Synchronous	0.75 (0.45, 1.24)	0.26	0.79 (0.58, 1.07)	0.12
OS
Age (<50 vs 50–60 vs >60)	1.28 (0.88, 1.86)	0.20	1.05 (0.84, 1.33)	0.65
KPS (<70 vs 70–80 vs >80)	0.35 (0.22, 0.55)	<0.001	0.70 (0.56, 0.89)	0.004
Brain mets (1 vs 2–3 vs >3)	0.95 (0.69, 1.31)	0.74	1.31 (1.08, 1.59)	0.006
Symptomatic	0.87 (0.48, 1.60)	0.66	0.97 (0.67, 1.40)	0.85
Synchronous	0.69 (0.40, 1.19)	0.18	0.83 (0.60, 1.15)	0.25