Table 3.

Multivariable analysis including ECM

PFS	EGFR/ALK+ NSCLC	P	Wild Type	P
	HR (95% CI)		HR (95% CI)
Age (<50 vs 50–60 vs >60)	0.81 (0.59, 1.13)	0.21	0.92 (0.74, 1.15)	0.48
KPS (<70 vs 70–80 vs >80)	0.59 (0.38, 0.92)	0.02	0.72 (0.58, 0.90)	0.004
Brain mets (1 vs 2–3 vs >3)	0.93 (0.70, 1.25)	0.65	1.17 (0.98, 1.41)	0.084
Symptomatic	1.06 (0.60, 1.87)	0.84	1.13 (0.79, 1.61)	0.50
Synchronous	0.72 (0.43, 1.18)	0.19	0.78 (0.57, 1.06)	0.11
ECM (yes/no)	0.51 (0.30, 0.87)	0.014	1.41 (1.03, 1.94)	0.031
OS
Age (<50 vs 50–60 vs >60)	1.28 (0.88, 1.88)	0.20	1.06 (0.84, 1.34)	0.62
KPS (<70 vs 70–80 vs >80)	0.35 (0.22, 0.55)	<0.001	0.69 (0.54, 0.87)	0.002
Brain mets (1 vs 2–3 vs >3)	0.95 (0.69, 1.31)	0.76	1.20 (0.99, 1.46)	0.063
Symptomatic	0.87 (0.48, 1.60)	0.66	1.09 (0.75, 1.59)	0.65
Synchronous	0.69 (0.40, 1.18)	0.18	0.80 (0.58, 1.11)	0.18
ECM (yes/no)	0.97 (0.54, 1.74)	0.91	1.95 (1.37, 2.77)	<0.001