Table 6.
ADME profiling of potent caffeic acid derivatives.
| Compound name | Ghose | TPSA | Absorption (% ABS) | Water solubilityLog S (ESOL) | BBB permeant | P-gp substrate | CYP isoform interact |
|---|---|---|---|---|---|---|---|
| Khaınaosıde C | No | 175.37 | 48.49 | -3.12- Soluble | No | Yes | No |
| Calceolarioside B | Yes | 186.37 | 44.70 | -2.85- Soluble | No | Yes | No |
| Vitexfolin A | No | 183.21 | 45.79 | -3.01- Soluble | No | Yes | No |
| 6-O-Caffeoylarbutin | Yes | 166.14 | 51.68 | -2.86- Soluble | No | Yes | No |
| Khaınaosıde B | No | 201.67 | 39.42 | -3.14- Soluble | No | Yes | No |
| Dodegranoside A | Yes | 166.14 | 51.68 | -2.86- Soluble | No | Yes | No |
| Chicoric acid | Yes | 208.12 | 37.19 | -3.58- Soluble | No | Yes | No |
| Eutıgosıde A | Yes | 145.91 | 58.66 | -3.11- Soluble | No | Yes | No |
| Nelfinavir | No | 127.20 | 65.18 | -6.36-Poorly soluble | No | Yes | 1A2, 2C19, 3A4 |