Table 2.

Potential targets for the analyzed molecules.

Compound	Potential target pathways
Zinc	Replication inhibition
	Immunomodulatory effects
	Intracellular redox activity
	Antibodies production
	NK cells activity
	Cytokines production by mononuclear cells
	Chemotaxis response reduction
	Neutrophil respiratory burst reduction
Resveratrol	Sirtuin deacetylase SIRT1 agonist
	AMPK activation
	PGC1alpha levels maintenance
	Mitochondrial biogenesis activation
	Mitophagy promotion
	ACE2 protein level increase
	DNA damage reduced
	Destabilization of p53 promoted
	Bax expression decreased
Hydroxytyrosol	Neutrophil respiratory burst effective-caused oxidative stress reduction
	Pulmonary fibrosis decrease
Curcumin	ACE2 level increase
	Antiviral activities
	SARS-CoV-2 protease, spike glycoprotein-RBD and PD-ACE2 binding
	Virus-ACE2 interaction reduction
	Antioxidant capacity
	Anti-inflammatory
Quercetin	Antiviral activity
	Autophagy promotion
	Virus-ACE2 interaction reduction
	Antioxidant capacity
	Anti-inflammatory
Vitamin C	Antioxidant capacity
	Biological processes related to the immune system
	Interferon production
	Cytokines production downregulated
Vitamin D	Cell physical barrier integrity maintenance
	Increased antimicrobial protein production
	Anti-inflammatory state
	ACE2 and other members of the RAS expression