Table 2.

Different dosing schedules explored in the combination of alpelisib and neratinib to treat triple-negative breast cancer (TNBC) cell lines.

Dosing regimen	Alpelisib	Neratinib
1	300 mg QD	240 mg QD
2	300 mg QD	120 mg QD
3	300 mg QD	360 mg QOD
4	300 mg QD	1200 mg QW
5	300 mg QD	720 mg QW + 40 mg QD r.m.
6	300 mg QD	720 mg QW + 80 mg QD r.m.
7	300 mg QD	720 mg QW + 160 mg QD r.m.
8	525 mg QOD	240 mg QD
9	900 mg QW + 200 mg QD r.m.	240 mg QD
10	900 mg QW + 200 mg QD r.m.	720 mg QW + 160 mg QD r.m.

^*QD: once a day, QW: once a week, QOD: every other day, r.m.: remaining of the week.