Table 3.

Univariate and multivariate logistic regression analysis for risk of having NSCLC.

	Univariate analysis			Multivariate analysis
	OR	OR 95% CI	p Value	OR	OR 95% CI	p Value Non corrected	p Value Bonferroni Correction
CDO1 methylated in plasma	3.96	1.54–10.49	0.005	4.90	1.73–4.77	0.003	0.023
TAC1 methylated in plasma	7.04	2.65–19.79	<0.001	9.22	3.11–230.63	<0.001	<0.001
HOXA7 methylated in plasma	15.20	5.05–57.34	<0.001	17.02	5.16–71.84	<0.001	<0.001
HOXA9 methylated in plasma	5.55	2.00–18.14	0.002	6.05	2.05–21.22	0.002	0.015
SOX17 methylated in plasma	6.99	2.65–19.65	<0.001	7.03	2.53–21.19	<0.001	0.002
ZFP42 methylated in plasma	5.37	1.54–20.09	0.009	5.13	1.32–021.49	0.019	0.135
At least 3 genes methylated in plasma	10.83	3.87–32.80	<0.001	13.56	4.33–549.21	<0.001	<0.001
CDO1 methylated in urine	4.34	1.73–11.41	0.002	6.69	2.31–22.02	<0.001	0.006
TAC1 methylated in urine	5.96	2.29–17.11	<0.001	5.30	1.87–16.84	0.003	0.018
HOXA7 methylated in urine	1.29	0.59–3.18	0.580	1.40	0.52–3.88	0.503	1.000
HOXA9 methylated in urine	4.04	1.47–13.15	0.011	4.33	1.46–15.17	0.013	0.088
SOX17 methylated in urine	7.47	2.87–20.78	<0.001	8.69	3.05–27.81	<0.001	<0.001
ZFP42 methylated in urine	3.10	0.88–10.92	0.073	3.82	0.98–15.57	0.053	0.374
At least 3 genes methylated in urine	5.56	1.66–20.33	0.006	5.76	1.60–22.73	0.008	0.059
CDO1 Plasma and Urine	7.45	2.55–27.45	<0.001	12.68	3.55–61.04	<0.001	0.003
TAC1 Plasma and Urine	13.76	3.71–89.64	<0.001	13.81	3.38–99.40	<0.001	0.010
HOXA7 Plasma and Urine	4.72	1.61–17.34	0.009	4.90	1.55–19.24	0.012	0.081
HOXA9 Plasma and Urine	9.63	1.85–177.47	0.031	10.19	1.83–192.57	0.031	0.217
SOX17 Plasma and Urine	14.41	4.47–65.06	<0.001	18.17	5.12–91.16	<0.001	<0.001
ZFP42 Plasma and Urine	2.57	0.87–7.41	0.081	2.76	0.86–8.82	0.083	0.581
At least 3 genes in Plasma and Urine	31.47	8.27–208.29	<0.001	69.34	13.21–721.89	<0.001	<0.001

Abbreviations: CI confidence Interval; OR Odds Ratio; NA non-applicable

Multivariate analysis adjusted by age, race and pack years