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. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: Biochim Biophys Acta Mol Basis Dis. 2020 May 19;1866(10):165841. doi: 10.1016/j.bbadis.2020.165841

Figure 1. Cytosolic and mitochondrial folate-mediated serine, glycine, and one-carbon cycle.

Figure 1.

Serine, and to a lesser extent glycine, provides 1C precursors for biosynthesis in the cytosol and mitochondria. Flux through either branch also maintains redox homeostasis through NAD(P)H consumption or generation. Important enzymes are highlighted in bold and italicized.