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. 2020 Aug 21;11:4183. doi: 10.1038/s41467-020-17876-0

Fig. 4. Cell-type-specific pathways associated with the genetic risk of three genetic brain disorders.

Fig. 4

Gene Ontology (GO) enrichment for cortex (a) and substantia nigra (SN) (b) cell-type-specific protein–protein interaction (PPI) gene modules enriched in Parkinson’s disease (PD), schizophrenia (SCZ) and bipolar (BP) disorders risk. We tested the convergence of disease genetic risk at a functional level across cell-type-specific PPI gene modules using MAGMA gene set analysis (one-sided positive two-sample t-test); an asterisk (*) and double asterisks (**) indicate nominally significant p value (<0.05) and q value (Bonferroni correction for the number of cell-type PPI modules tested), respectively. The top representative GO biological process terms are shown for cell-type modules with either PD, SCZ or BP risk enrichment that reached significance in the more general cell-type level analysis (Fig. 2). Tests across all identified gene modules are reported in Supplementary Fig. 10, and complete lists of enriched GO terms are reported in Supplementary Data 6 and 7. The size of circles represents −log(p value) for GO enrichment with Fisher test; colours correspond to cell types (DaNs dopaminergic neurons, Ex excitatory neurons, GABA GABAergic neurons, In: inhibitory neurons, ODC oligodendrocytes, OPC oligo-precursor cells).