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. 2020 Aug 21;10:14070. doi: 10.1038/s41598-020-70987-y

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Histological time course of the development of D2.mdx skeletal muscle pathology. (a) Hematoxylin and eosin (H&E) stained sections of 1 month-old D2.mdx diaphragm and gastrocnemius (Gastroc) exhibiting inflammation without signs of degeneration. (b) Masson’s trichrome staining of 2 month-old samples reveal large degenerating lesions that precede the development of fibrosis. (c) H&E and picrosirius red staining of 3 month-old skeletal muscle showing major histopathological features following recovery from the degenerative stage. (d) Quantification of centrally-located nuclei in the diaphragms and Gastrocs of 3, 4, 6, and 12 mo D2.mdx mice (n = 5–12). Data were analyzed using one-way ANOVA and presented as mean ± SEM. Scale bars represent 100 µm.