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. 2020 Aug 21;11(8):673. doi: 10.1038/s41419-020-02800-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a MTT cell viability dilution curves with increasing concentrations of JQ1 and ICG-001, as indicated. H3K27M-mut-DIPG cells were treated with ICG-001 and JQ1, as indicated and subjected to MTT cell viability assay with H3K27M-mut-DIPG cells grown under (b) stemness- (gliomaspheres) and (c) differentiation- (monolayer) conditions. *p < 0.05 with respect to DMSO-treated control cells, #p < 0.05 with respect to ICG-001 or JQ1-treated cells, as indicated. d Protein expression of cleaved PARP apoptosis marker in H3WT-pedHGG and H3K27M-mut-DIPG cells after ICG-001 and JQ1 treatment, as indicated; β-actin served as loading control.