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. 2020 Aug 21;11(8):673. doi: 10.1038/s41419-020-02800-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a–c GSEA plots showing enrichment of super enhancer programs in control compared with treatment (a) of JQ1, (b) ICG-001, and (c) combinatorial treatment. d Significant clusters showing different patterns of gene expression regulation upon treatment with DMSO, JQ1, ICG-001, or combined ICG-001/JQ1 treatment. Asterisks mark genes that promote GBM characteristics. Bold and colored genes promote other tumor entities. e Genes of four clusters differentially regulated by ICG-001, JQ1, and combinatorial treatment and their function in GBM pathogenesis^52–73.