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. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: Biol Psychiatry. 2020 Feb 21;88(7):576–586. doi: 10.1016/j.biopsych.2020.02.011

Figure 5.

Figure 5.

Region-of-interest (ROI) identification. (A) An omnibus F test was conducted to identify brain regions showing greater responses in either aversrve and reappraisal vs. neutral conditions. Significant activation (p < .005; minimum cluster size = 87 voxels or 696 mm3) was detected in the bilateral amygdala, bilateral dorsolateral prefrontal cortex (DLPFC). bilateral insula, bilateral caudate, bilateral dorsomedial PFC (DMPFC). left ventrolateral PFC (VLPFC). right supramarginal gyrus, bilateral precuneus, and bilateral occipital cortices. (B) ROIs were centered (6-mm radii) around activation peaks in the amygdala (Montreal Neurological Institute coordinates: [−24, −6, −14] and [22, −6, −14]) and DLPFC (Montreal Neurological Institute coordinates: [−42, 12, 44] and [40, 8, 38]). (C) Companson of DLPFC ROIs from the present study with those identified in previous meta-analysis studies of emotion regulation (7–10,41). Our DLPFC ROIs were localized to the middle frontal gyrus/inferior frontal function (55). L, left: R, right.