Table 2b.

Affinity of analogs at serotonin receptors

				Ki (nM)a
Cmpd #	R1	R2	R3	5-HT1Ab	5-HT1Bc	5-HT2Ad	5-HT5Ae	5-HT6e
10	OMe	OMe	H	110	255	1680	578	5
11	OH	OH	H	151	451	1564	244	38
12	OMe	OMe	Me	NAf	NA	811	286	5
13	OH	OH	Me	393	1032	352	363	123
8-OH-DPAT				0.81
ergotamine					9.28		6.92
clozapine						3.91		3.88

^a.Experiments conducted in triplicate; SEM values are within 15% of reported values;

^b.[3H]-WAY100635 used as radioligand;

^c.[3H]GR125743 used as radioligand;

^d.[3H]ketanserin used as radioligand;

^e.[3H]LSD used as radioligand;

^f.NA- not active- ligands displayed <10% inhibition in a primary assay at a ligand concentration of 10 μM