Table 2c.

Affinity of analogs at α-adrenergic receptors

				Ki (nM)a.
Cmpd #	R1	R2	R3	α1Ab	α1Bb	α2Ac	α2Bc	α2Cc
10	OMe	OMe	H	545	2592	1603	1120	774
11	OH	OH	H	3197	NAd	2590	2197	1106
12	OMe	OMe	Me	2863	5874	1174	NA	472
13	OH	OH	Me	>10,000	NA	NA	5822	1959
prazosin				0.38	0.39
oxymetazoline						9.30		65.58
yohimbine							10.85

^a.Experiments conducted in triplicate; SEM values are within 15% of reported values;

^b.[3H]Prazosin used as radioligand;

^c.[3H]Rauwolscine used as radioligand;

^d.NA- not active- ligands displayed <10% inhibition in a primary assay at a ligand concentration of 10 μM