Table 3.
Univariate and multivariable logistic regression models for brain metastasis in patients with EAC (n=1502)
| Univariate | Multivariable | |||
|---|---|---|---|---|
| Clinical feature | OR (95% CI) | p | OR (95% CI) | p |
| Agea | 0.98 (0.96–1.00) | 0.03 | 0.98 (0.96–1.00) | 0.07 |
| Sex | ||||
| Male | 1 (reference) | |||
| Female | 0.88 (0.37–2.08) | 0.77 | ||
| Location of tumor | ||||
| Proximal Esophagus | 2.20 (0.83–5.85) | 0.11 | 2.30 (0.86–6.19) | 0.09 |
| Siewert type I | 2.72 (1.48–5.01) | 0.001 | 2.44 (1.31–4.54) | 0.005 |
| Siewert type II | 1 (reference) | 1 (reference) | ||
| Tumor differentiation | ||||
| Well/moderate | 1 (reference) | |||
| Poor | 0.77 (0.47–1.29) | 0.33 | ||
| Signet ring cell carcinoma | ||||
| No | 1 (reference) | |||
| Yes | 0.88 (0.43–1.82) | 0.75 | ||
| Baseline T category | ||||
| T1/2 | 1 (reference) | 1 (reference) | ||
| T3/T4 | 6.34 (1.98–20.4) | 0.0019 | 2.62 (0.74–9.26) | 0.13 |
| Baseline N category | ||||
| N0 | 1 (reference) | 1 (reference) | ||
| N1/N2/N3 | 5.20 (2.46–11.0) | <0.0001 | 3.32 (1.48–7.47) | 0.003 |
| Baseline clinical stage | ||||
| I/II | 1 (reference) | |||
| III/IVA | 16.99 (2.33–123.7) | 0.005 | ||
| IVB | 18.41 (2.44–138.8) | 0.005 | ||
CI, confidence interval; OR, odds ratio.