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. Author manuscript; available in PMC: 2020 Dec 18.
Published in final edited form as: Nature. 2020 Jun 18;584(7821):437–442. doi: 10.1038/s41586-020-2456-9

Extended Data Figure 8. Analysis of antibody somatic hypermutation and CDR3 length.

Extended Data Figure 8.

a, For each individual, the number of somatic nucleotide mutations (Y axis) at the IGVH and IGVL are shown on the left panel, and the amino acid length of the CDR3s (Y axis) are shown on the right panel. The horizontal bars indicate the mean. The number of antibody sequences (IGVH and IGVL) evaluated in each participant are n=118 (COV107), n=127 (COV21), n=79 (COV47), n=54 (COV57), n=78 (COV72), n=78 (COV96). b, same as in a but for all antibodies combined (n=534 for both IGVH and IGVL). c, Distribution of the hydrophobicity GRAVY scores at the IGH CDR3 in antibody sequences from this study compared to a public database (see Methods for statistical analysis). The box limits are at the lower and upper quartiles, the center line indicates the median, the whiskers are 1.5x interquartile range and the dots represent outliers.