Figure 4.

Meta-analysis of association between 30 diet-associated CpGs and all-cause mortality in 10 cohorts of European ancestry participants (n≈10,000). A positive sign for diet indicates that a higher dietary scores (MDS or AHEI, or both) were associated with DNA hypermethylation, whereas, a hazard ratio of over 1.0 indicates that DNA hypermethylation was associated with increased all-cause mortality. Models were adjusted for baseline covariates including sex, age, smoking status, physical activity level, alcohol intake, BMI, and prevalence disease status of hypertension, type 2 diabetes, cardiovascular disease, and cancer. Estimated leukocyte counts, technical variables, and kinship (for related study samples) were also considered. Hazard ratios and 95% confidence interval were estimated using Cox proportional hazard models and meta-analyzed using random effect models. X-axis is in logarithmic scale.