Table 1.
Diet scores-associated CpGs in European Ancestry (EA) meta-analysis
| CpG | CHR | Position | Gene | Diet | Meta-analysis in all EA participants | ||||
|---|---|---|---|---|---|---|---|---|---|
| Beta | SE | P | Direction | I-squared | |||||
| cg04885881 | 1 | 11123118 | MDS | 0.004 | 0.001 | 3.2E-07 | +, +, +, +, + | 0.12 | |
| cg24735226 | 1 | 65096537 | CACHD1 | AHEI | −0.004 | 0.001 | 1.6E-06 | −, −, −, −, − | 0 |
| cg07805029 | 1 | 92953256 | GFI1 | AHEI | 0.003 | 0.001 | 3.1E-06 | +, +, +, +, + | 0 |
| cg19693031 | 1 | 145441552 | TXNIP | MDS | 0.003 | 0.001 | 3.1E-07 | +, +, +, +, + | 0.14 |
| cg24694018 | 1 | 145457621 | POLR3GL | AHEI | 0.002 | 0.0003 | 8.3E-07 | +, +, +, +, + | 0 |
| cg01940273 | 2 | 233284934 | MDS | 0.005 | 0.001 | 1.6E-12 | +, +, +, +, + | 0 | |
| cg20842915 | 7 | 39665132 | RALA | AHEI | 0.003 | 0.001 | 8.1E-08 | +, +, +, +, + | 0 |
| cg02508743 | 8 | 56903623 | LYN | AHEI | −0.002 | 0.001 | 2.5E-06 | −, −, −, −, − | 0 |
| cg27039118 | 8 | 116575902 | TRPS1 | AHEI | 0.004 | 0.001 | 1.2E-06 | +, +, +, +, + | 0 |
| cg02716826 | 9 | 33447032 | SUGT1P1;AQP3 | MDS | 0.002 | 0.0005 | 5.6E-07 | +, +, +, +, + | 0 |
| cg25953130 | 10 | 63753550 | ARID5B | AHEI | 0.004 | 0.001 | 1.2E-08 | +, +, +, +, + | 0 |
| cg03190891 | 10 | 97201172 | SORBS1 | AHEI | −0.003 | 0.0005 | 9.0E-08 | −, −, −, −, − | 0 |
| cg02079413 | 11 | 2986505 | SNORA54;NAP1L4 | MDS | −0.002 | 0.0004 | 3.1E-07 | −, −, −, −, − | 0.14 |
| cg11250194 | 11 | 61601937 | FADS2 | AHEI | 0.003 | 0.001 | 1.5E-06 | +, +, +, +, + | 0 |
| cg11468085 | 11 | 67435577 | ALDH3B2 | AHEI | −0.002 | 0.0005 | 1.4E-06 | −, −, −, −, − | 0.06 |
| cg25909064 | 11 | 120082805 | OAF | AHEI | 0.002 | 0.0004 | 8.0E-07 | +, +, +, +, + | 0 |
| cg03646329 | 13 | 48987165 | LPAR6;RB1 | AHEI | 0.003 | 0.001 | 1.5E-06 | +, +, +, +, + | 0 |
| MDS | 0.004 | 0.001 | 1.1E-06 | +, +, +, +, + | 0 | ||||
| cg16969872 | 13 | 79968324 | RBM26 | AHEI | 0.003 | 0.001 | 3.0E-09 | +, +, +, +, + | 0 |
| MDS | 0.003 | 0.001 | 1.2E-06 | +, +, +, +, + | 0.25 | ||||
| cg09940677 | 14 | 103415458 | CDC42BPB | AHEI | −0.001 | 0.0003 | 2.9E-06 | −, −, −, −, − | 0 |
| cg13074055 | 14 | 106329206 | AHEI | 0.005 | 0.001 | 1.3E-06 | +, +, +, +, + | 0 | |
| cg27118035 | 16 | 31891978 | ZNF267 | AHEI | −0.003 | 0.0005 | 4.9E-09 | −, −, −, −, − | 0 |
| cg08732950 | 16 | 89023389 | CBFA2T3 | MDS | −0.003 | 0.0005 | 2.8E-08 | −, −, −, −, − | 0 |
| cg02097604 | 17 | 17750910 | TOM1L2 | AHEI | 0.002 | 0.0003 | 6.6E-09 | +, +, +, +, + | 0 |
| MDS | 0.002 | 0.0003 | 3.6E-08 | +, +, +, +, + | 0 | ||||
| cg16936953 | 17 | 57915665 | VMP1 | AHEI | 0.004 | 0.001 | 1.5E-08 | +, +, +, +, + | 0 |
| cg18181703 | 17 | 76354621 | SOCS3 | AHEI | 0.004 | 0.001 | 2.0E-12 | +, +, +, +, + | 0 |
| MDS | 0.004 | 0.001 | 3.5E-10 | +, +, +, +, + | 0 | ||||
| cg19202384 | 17 | 79894511 | PYCR1 | AHEI | 0.002 | 0.0004 | 9.9E-07 | +, +, +, +, + | 0.04 |
| cg01294327 | 19 | 2291373 | LINGO3 | AHEI | 0.005 | 0.001 | 1.4E-06 | +, +, +, +, + | 0 |
| cg26470501 | 19 | 45252955 | BCL3 | AHEI | 0.002 | 0.0004 | 2.4E-06 | +, +, +, +, + | 0.03 |
| cg08884571 | 19 | 45901453 | PPP1R13L | AHEI | −0.004 | 0.001 | 4.6E-07 | −, −, −, −, − | 0 |
| cg05232694 | 20 | 48809539 | AHEI | 0.004 | 0.001 | 3.1E-08 | +, +, +, +, + | 0 | |
Genome build 37. Regression coefficients are DNA methylation change for per standard deviation change in diet scores from analyses using sex, age, and energy intake adjusted models. Direction order (from left to right): FHS, ARIC, GOLDN, MESA, and RS. AHEI: Alternative Healthy Eating Index. MDS: Mediterranean-style diet score