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. Author manuscript; available in PMC: 2021 Aug 19.
Published in final edited form as: Neuron. 2020 Jun 10;107(4):731–744.e3. doi: 10.1016/j.neuron.2020.05.023

Fig. 2. Cooling of MS affects theta oscillations.

Fig. 2.

a, Components of the cooling probe. b, Cooling probe and thermocouple are implanted in MS and silicon probes in the hippocampus. Dry ice is placed into the reservoir and MS is cooled by thermal conduction. c, Maze with left (blue) and right (green) run trajectories superimposed. d, top panel: Time-resolved spectrogram in a single session. Color scale is normalized. Middle panel: temperature; lower panel: running speed of animal. e, Frequency spectrum with power of theta and its 1st–3rd harmonics (arrows). f, Power spectra of the theta band and harmonics before (top) and after (bottom) cooling. Color scale is normalized. Same single session used in d,e,f. g, h, Effect of MS cooling on theta frequency (g) and power (h) Group data for all sessions and subjects (mean values with SE). i, Group data for theta frequency and power before, during and after MS cooling. g,h,i,j: 53 sessions in 5 rats. j, R and P values for theta frequency and power in individual rats (color coded).