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. Author manuscript; available in PMC: 2021 Feb 15.
Published in final edited form as: Clin Cancer Res. 2020 May 19;26(16):4390–4401. doi: 10.1158/1078-0432.CCR-19-3104

Figure 4: Macrophages/microglia in tumors that develop in the absence of CD8+ T-cells have an enriched pro-inflammatory phenotype.

Figure 4:

(A) Box plot showing RPKM gene expression standardized score. (B) GSEA employing the tumor inflammation signature between animals treated with anti-CD8+ and isotype control antibodies. (C) GSEA (left) and heatmap (right) evaluating the expression signature of pro-inflammatory phenotype in macrophages/microglia in tumors developed in the absence of CD8+ T-cells and the isotype control (left, NES=1.785; FDR<0.001), (n=15). Data in (A) is shown as mean ± SEM, p=0.0106 by 2-way ANOVA test. p= 0.033 in (B) and p<0.001 in (C), two-sided Kolmogorov-Smirnov test.