Table 1.
Main findings for association with eGFR at p<10−7 using TOPMed reference imputation in the HCHS/SOL (n=12,207)
| Ch | Position (hg38) |
SNPID | Coded allele |
Non-coded | AF coded | beta | P | Nearby Gene |
Function | 1000 Genome Project allele frequencies | Replication WHI AA (n=8,224) | Replication WHI HA (n=3,549) | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AFR | AMR | EUR | Beta (SE), P | Beta (SE), P | ||||||||||
| 2 | 191304743 | rs566396416 | A | G | 0.002 | −12.801 (2.523) | 3.8×10−7 | MYO1B | intronic | NA | NA | NA | NA | NA |
| 5 | 113371933 | rs17379925 | T | C | 0.02 | 3.159 (0.645) | 9.0 ×10−7 | MCC | intronic | 0.005 | 0.02 | 0.05 | NA | 1.135 (1.143), 0.32 |
| 5 | 171905787 | rs77109276 | G | A | 0.01 | −4.179 (0.847) | 8.2 × 10−7 | FBXW11 | intronic | NA | 0.006 | 0.03 | NA | 2.600 (1.408), 0.06 |
| 6 | 34250388 | rs10080749 | G | A | 0.33 | −0.987 (0.200) | 8.0 × 10−7 | C6orf1 | intergenic | 0.52 | 0.37 | 0.12 | NA | − 0.249 (0.357), 0.49 |
| 6 | 54013111 | NA | AT | A | 0.001 | −20.946 (4.233) | 7.5 × 10−7 | MLIP | intergenic | NA | NA | NA | NA | NA |
| 7 | 128864667 | rs537479423 | T | C | 0.002 | −12.396 (2.282) | 5.6 × 10−8 | ATP6V1F | intronic | 0.01 | 0.003 | NA | NA | NA |
| 7 | 151442610 | rs145127841 | A | G | 0.006 | −6.862 (1.3890) | 7.8 × 10−7 | CRYGN | intergenic | 0.03 | 0.006 | NA | NA | NA |
| 10 | 25871827 | rs150486305 | T | G | 0.003 | 9.716 (1.934) | 5.0 × 10−7 | LOC101929073 | intergenic | NA | 0.001 | 0.001 | NA | NA |
| 11 | 57930162 | NA | T | C | 0.001 | −17.786 (2.283) | 6.0 × 10−8 | OR9Q1 | intergenic | NA | NA | NA | NA | NA |
| 11 | 58498757 | NA | G | A | 0.001 | −17.028 (3.223) | 1.3 × 10−7 | OR5B21 | intergenic | NA | NA | NA | NA | NA |
| 13 | 88310365 | rs530730032 | G | A | 0.002 | −12.862 (2.555) | 4.8 × 10−7 | LINC00433 | intergenic | 0.005 | NA | NA | NA | NA |
| 13 | 112853280 | rs560559296 | G | A | 0.001 | −14.559 (2.730) | 9.6 × 10−8 | ATP11A | intronic | NA | 0.001 | 0.005 | NA | NA |
| 15 | 32721018 | rs11857586 | A | T | 0.02 | 3.527 (0.706) | 5.9 × 10−7 | GREM1 | intronic | 0.15 | 0.01 | 0.002 | −0.865 (0.498), 0.08 | −0.401 (1.229), 0.74 |
| 15 | 34926038 | rs58720902 | T | G | 0.01 | 4.791 (0.847) | 1.6 × 10−8 | AQR | intronic | 0.11 | 0.01 | 0.00 | 0.086 (0.523), 0.86 | 1.97 (6.49), 0.03 |
| 20 | 4739670 | rs2422935 | A | G | 0.54 | −0.965 (0.188) | 3.0 × 10−7 | PRNT | ncRNA intronic | 0.53 | 0.54 | 0.55 | −0.346 (0.278), 0.21 | −0.877 (0.314), 0.005 |
Abbreviations: AF, allele frequency; Chr, chromosome; P, p-value; AFR, African; AMR, Admixed Americans; EUR, European; AA, African American; HA, Hispanics; SE, standard deviation