Table 2.

Main findings for association with ACR at p<10⁻⁷ using TOPMed reference imputation in the HCHS/SOL (n=11,688)

Chr	Position (hg38)	SNPID	Coded allele	Non-coded	AF coded	beta	P	Nearby Gene	Function	1000 Genome Project allele frequencies			Replication UK Biobank P
										AFR	AMR	EUR
2	27346004	rs10205592	C	T	0.56	−0.075 (0.014)	1.1×10−7	GTF3C2	intronic	0.87	0.51	0.41	NA
2	108390209	rs13021399	T	A	0.56	−0.081 (0.015)	9.9×10−8	SULT1C4	intergenic	0.02	0.53	0.26	0.36
2	108897145	rs3827760	G	A	0.29	0.097 (0.019)	1.6×10−7	EDAR	missense	0.003	0.39	0.01	0.10
2	109624640	rs919942	A	C	0.63	0.071 (0.014)	8.2×10−7	SOWAHC	intergenic	0.33	0.69	0.54	0.52
2	111121122	rs116907128	A	C	0.14	0.120 (0.022)	3.5×10−8	BCL2L11	UTR5	0.002	0.17	0.001	NA
3	196146539	rs540878340	A	G	0.002	0.914 (0.176)	2.0 × 10−7	LINC00885	ncRNA_intronic	0.02	0.001	NA	NA
11	5227002	rs334	A	T	0.01	0.530 (0.082)	8.4 ×10−11	HBB	missense			NA	NA
11	103974051	rs7103465	A	G	0.03	0.248 (0.049)	3.7 × 10−7	PDGFD	intronic	0.11	0.02	0.02	0.41
11	114155245	rs527493184	A	G	0.002	1.029 (0.180)	1.1 × 10−8	ZBTB16	intronic	0.01	0.003	NA	NA
16	86734887	rs11117207	C	T	0.08	−0.128 (0.025)	3.6 × 10−7	FOXL1	intergenic	0.27	0.08	0.04	0.62
17	54416610	rs115573116	T	C	0.002	0.756 (0.145)	1.7 × 10−7	TOM1L1	intergenic	0.03	0.001	NA	NA
22	16823805	rs1032642268	A	G	0.002	0.873 (0.176)	7.1 × 10−7	XKR3	intergenic	NA	NA	NA	NA

Abbreviations: AF, allele frequency; Chr, chromosome; P, p-value; 1kg, 1000 Genome Project; AA, African American; HA, Hispanics; SE, standard deviation; UKB, UK Biobank; AFR, African; AMR, Admixed Americans; EUR, European