Table 2:

Candidate genes and their protein’s primary function

Gene	Full name	Reference SNP cluster ID	Protein function
IL6	Interleukin 6	rs1800796	Pro-inflammatory cytokine
CCL3	C-C motif chemokine ligand 3	rs1719134	Chemokine involved in recruitment and activation of granulocytes
HCP5	HLA complex P5	rs2395029	A human endogenous retrovirus. Variants confer protection against AIDS
CX3CR1	C-X3-C motif chemokine receptor 1	rs3732379	Chemokine involved in adhesion and migration of leukocytes
HFE	Homeostatic iron regulator	rs1799945	Regulates circulating iron uptake via regulating interaction between transferrin receptor and transferrin
NFE2L2	Nuclear factor, erythroid 2 like 2	rs6706649	Transcription factor that regulates expression of antioxidant proteins in response to injury and inflammation
CXCL12	C-X-C motif chemokine ligand 12	rs1801157	Chemokine that activates leukocyte migration in CNS as part of inflammatory activation
CCR2	C-C motif chemokine receptor 2	rs1799864	Chemokine that mediates monocyte chemotaxis
BDNF	Brain derived neurotrophic factor	rs6265	Supports cell survival in CNS
HEPH	Hephaestin	rs1264212	Involved in metabolism and homeostasis of iron
TNF	Tumor necrosis factor	rs1800629	Pro-inflammatory cytokine
CD33	CD33 molecule (SIGLEC3)	rs3865444	Involved in inhibition of phagocytosis within cells
CCL2	C-C motif chemokine ligand 2	rs1024611	Pro-inflammatory cytokine
MBL2	Mannose binding lectin 2	rs1800450 rs1800451 rs5030737	Involved in innate immune response
APOE	Apolipoprotein E	rs429358 rs7412	Involved in lipid transport and metabolism

SNP single nucleotide polymorphism, CNS central nervous system