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. Author manuscript; available in PMC: 2021 Feb 15.
Published in final edited form as: Clin Cancer Res. 2020 Apr 6;26(16):4360–4368. doi: 10.1158/1078-0432.CCR-20-0175

Table 2.

Markers significantly associated with PFS and/or OS benefit under PD-1 checkpoint blockade

Markers associated with PFS benefit
Compartment Marker Cutpoint Log-rank
p 		Adjusted
Log-rank p 		Univariate
HR
(CI 95%)		 p Adjusted
p 		Multivariate
HR
(CI 95%)		 p
Tumor compartment VISTA Top tertile 0.001 0.014 2.60 (1.37-4.92) 0.003 0.043 2.49 (1.15-5.40) 0.020
CD127 Top tertile 0.001 0.014 2.65 (1.41-4.98) 0.002 0.043 2.39 (1.07-5.34) 0.033
CD45 compartment CD56 Top tertile 0.004 0.124 0.38 (0.18-0.80) 0.011 0.341 0.24 (0.08-0.66) 0.006
CD4 Median <0.001 <0.001 0.33 (0.16-0.67) 0.002 0.062 0.31 (0.12-0.76) 0.011
ARG1 Median 0.006 0.18 0.43 (0.21-0.86) 0.018 0.279 0.37 (0.16-0.83) 0.016
CD68 compartment CTLA4 Top tertile 0.023 0.736 1.95 (1.01-3.77) 0.044 0.858 2.36 (1.06-5.25) 0.035
Markers associated with OS benefit
Compartment Marker Cutpoint Log-rank
p 		Adjusted
Log-rankp 		Univariate
HR
(CI 95%)		 p Adjusted
p 		Multivariate
HR
(CI 95%)		 p
Tumor compartment STING Top tertile 0.002 0.058 0.31 (0.14-0.69) 0.004 0.116 0.33 (0.12-0.89) 0.029
CD45 compartment CD45 Median 0.003 0.022 0.35 (0.16-0.73) 0.005 0.045 0.47 (0.15-1.44) 0.19
CD56 Top tertile 0.033 0.127 0.44 (0.20-0.97) 0.044 0.169 0.26 (0.09-0.75) 0.014
PD-L1 Median 0.038 0.167 0.48 (0.23-0.99) 0.049 0.20 0.43 (0.15-1.23) 0.11
CD68 Top tertile 0.024 0.119 0.43 (0.20-0.93) 0.033 0.159 0.16 (0.05-0.47) 0.001
CD4 Median 0.001 0.015 0.31 (0.15-0.66) 0.002 0.030 0.23 (0.08-0.66) 0.007
B2M Median 0.001 0.015 0.28 (0.12-0.61) 0.002 0.030 0.35 (0.12-0.96) 0.041
CD20 Median 0.008 0.048 0.38 (0.18-0.82) 0.014 0.084 0.83 (0.32-2.16) 0.71
CD3 Median <0.001 <0.001 0.24 (0.11-0.53) <0.001 <0.001 0.24 (0.09-0.64) 0.005
CD8 Top tertile 0.016 0.117 0.38 (0.17-0.87) 0.023 0.159 0.54 (0.21-1.39) 0.20
TIM3 Median 0.003 0.022 0.32 (0.14-0.72) 0.006 0.045 0.62 (0.24-1.60) 0.32
CD40 Median 0.039 0.167 0.48 (0.24-0.99) 0.049 0.20 0.47 (0.17-1.28) 0.14
ICOS Top tertile 0.006 0.093 0.35 (0.16-0.78) 0.010 0.155 0.26 (0.08-0.79) 0.018
CD68 compartment CD45 Top tertile 0.004 0.064 0.33 (0.15-0.74) 0.008 0.128 0.31 (0.11-0.87) 0.026
PD-L1 Top tertile 0.035 0.243 0.45 (0.21-0.98) 0.045 0.288 0.55 (0.22-1.39) 0.17
CD20 Top tertile 0.004 0.064 0.33 (0.14-0.74) 0.007 0.128 0.56 (0.21-1.45) 0.23
GNZB Top tertile 0.023 0.243 0.42 (0.18-0.93) 0.032 0.288 0.55 (0.20-1.47) 0.23