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. Author manuscript; available in PMC: 2021 Feb 15.
Published in final edited form as: Clin Cancer Res. 2020 May 21;26(16):4326–4338. doi: 10.1158/1078-0432.CCR-20-0071

Figure 2.

Figure 2.

Relationships between densities of intraepithelial and stromal immune cells and clinicopathologic features. (A) Boxplots of the distribution of intraepithelial (IEL) and stromal (S) immune cell densities. (B) Correlation matrix of Spearman correlation coefficients between the densities of intraepithelial and stromal immune cells. (C) Heatmap of the relationships between clinicopathologic features and the densities of lymphocytes, plasma cells, neutrophils, and eosinophils. P values are based on the correlation analysis of immune cell densities and continuous or ordinal variables (AJCC Stage, Neoantigen load) by Spearman rank correlation test or the comparison of immune cell densities across categorical variable categories (Tumor location, Tumor differentiation, MSI status, CIMP status) by the Kruskal-Wallis test or Wilcoxon rank-sum test.