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. Author manuscript; available in PMC: 2021 Aug 21.
Published in final edited form as: ACS Chem Biol. 2020 Jul 9;15(8):2031–2040. doi: 10.1021/acschembio.0c00486

Figure 2.

Figure 2.

Application of Gini coefficients to quantify the cellular selectivity of SMIRNAs. A) Selectivity of TGP-515 (1 μM, the IC50) in MCF-7 cells generated from RT-qPCR profiling data as shown by the Volcano plot (left panel) and the Lorenz curve (right panel). TGP-515 binds to adjacent loops (highlighted in orange and blue) near the Drosha processing site of pri-miR-515. B) Selectivity of 96-SM (40 μM, the IC50) in MCF-7 cells via change in expression plot (left panel) and Lorenz curve (right panel) generated from RT-qPCR profiling data. 96-SM binds to an internal loop in the Drosha processing site of pri-miR-96 (highlighted in purple). C) Selectivity of 544-SM (0.02 μM, the IC80) in MDA-MB-231 triple negative breast cancer cells via change in expression plot (left panel) and Lorenz curve (right panel) generated from microarray profiling data. 544-SM binds to an internal loop in the Dicer processing site of pre-miR-544 (highlighted in green).