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. Author manuscript; available in PMC: 2021 Aug 21.
Published in final edited form as: J Org Chem. 2020 Aug 5;85(16):10451–10465. doi: 10.1021/acs.joc.0c00415

Table 4:

Scope of Phenol Nucleophiles[a]

graphic file with name nihms-1614303-t0009.jpg
[a]

Standard conditions: 1 (1.0 equiv., 0.50 mmol), 8a–j (3.0 equiv., 1.5 mmol), DCB (0.25 M, 2.0 mL), Co(acac)2 (10 mol%, 0.050 mmol), temperature as indicated, for 24 h under an O2 atmosphere. The selectivity of alcohol:ketone was determined by 19F NMR analysis of the crude reaction mixture and is reported in parentheses. Yields of pure isolated product represent the average of 2 runs.

[b]

Co(acac)2 (20%, 0.10 mmol).

[c]

36 h.

[d]

48 h.