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. 2020 Aug 21;11:4195. doi: 10.1038/s41467-020-18025-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Schematic of sensory neural signal recording during mechanical stimulation. b Long-term neural signal recordings with strong and weak mechanical stimuli. c SNR of neural signals with strong and weak stimuli at 0, 3, and 6 weeks of implantation (n = 5 independent experiments). The centerline represents the median, the bounds of the box represent the upper and lower quartiles, the whiskers represent minimum and maximum values, and the hollow circle shows dot plots. Error bars represent S.D. d Sequential images for hind limb movement induced by electrical stimulation (80 μA, 100 Hz) at 7 weeks of implantation. e Plot of normalized muscle force as a function of stimulation frequency. The parameters involved in neural stimulation are pulse width (PW, 0.25 ms), biphasic pulse amplitude (PA, 80 μA), stimulation period (0.5 s), repetition stimulation periods (SP, 5, 10, 20, 50, and 100 Hz), and stimulation current (1.14 μC/cm²). f Changes in SNR performance before and after electrical stimulation (stimulation pulses: 100,000). Data are represented as mean ± S.D. Statistical analysis was performed using one-way ANOVA with Tukey’s multiple comparison test (n = 14 independent experiments, P = 0.7795, NS (not significant) P > 0.05). g Synchronous neural signal and joint position recording of treadmill gait after 7 weeks of implantation. Real-time analysis for joint position and knee/ankle angle changes of a live rat without (h) and with (i) electrical stimulation after 7 weeks of implantation. Source data are provided as a Source Data file.