. 2019 Sep 27;71(5):1243–1247. doi: 10.1093/cid/ciz943

Table 3.

Factors Associated With Neurosyphilis, Defined as Cerebrospinal Fluid (CSF) White Blood Cells >20/uL or Reactive CSF-venereal Disease Research Laboratory Test at the Index Episode

Factor	Odds Ratio (95% CI), P Value	Adjusted Odds Ratio (95% CI), P Value
Previous syphilis (any stage)	0.52 (.34–.81), .004	0.43 (.27–.68), < .001
Previous late latent syphilis	1.66 (1.10–2.52), .02	NI^a
Treated for the index episode of syphilis before entry	0.51 (.35–.75), .001	0.47 (.32–.70), < .001
Serum rapid plasma reagin (per 2-fold titer increase)	1.26 (1.16–1.38), < .001	1.29 (1.18–1.41), < .001
Stage (early vs late)	0.47 (.30–.73), .001	NI^a
People living with HIV vs people not living with HIV	0.67 (.43–1.03), .07	NI^a

Abbreviations: CI, confidence interval; NI, not included in final model.

^aNot included in the final model because P > .05 in the initial multivariate analysis.