. 2020 Aug 5;9(9):9. doi: 10.1167/tvst.9.9.9

Table 2.

Retinal HSI Findings as Mentioned in the Literature; Most Cited Ones and Human Studies Are Listed Higher

Ophthalmologic Disease	Pathologic Structures
Primary open angle glaucoma (oximetry)³⁰^,⁵³ Dry and wet ARMD²³ Retinitis pigmentosa²³ Chronic iridocyclitis²³ Stargardt's disease⁶⁹ Radiation related retinopathy⁵⁹ Choroidal melanoma⁷⁹ ARMD and ARM³³^,⁶⁵^,⁶⁶^,⁷⁸	Sub-RPE deposits and peripheral drusen (autofluorescence)³³^,⁶⁵ Flecken in Stargardt's disease, drusen in fibulin 3 deficiency and membranoproliferative glomerulonephritis type 2 versus drusen in ARMD⁶⁹ Drusen in ARMD⁶⁵^,⁶⁹ Optic nerve head drusen⁷⁶ Drusen in ARMD⁸⁸
	Physiologic Findings
	Oximetry²⁶^,³⁶^,⁵⁰^,⁵¹^,⁵⁷^,⁵⁸^,⁶⁰^,⁷⁶^,⁷⁷^,⁸⁷ Macular pigment (lutein and zeaxanthin)²⁴^,⁷⁶^,⁸⁷ Cytochrome C in retinal neuron culture²⁹ Organoid maturation in stem cells (free NADH, retinol and retinoic acid)⁸⁰ Fluorophore families (as lipofuscin, melanolipofuscin) in RPE⁴⁶^,⁴⁷ Oximetry while elevating IOP⁷⁰^–⁷³ Lymphatic drainage in the eye⁶⁴ Oximetry²⁵^,⁷⁰^,⁸⁶
Ocular Pathology as a Manifestation of a Systemic Disease
(Proliferative) Diabetic retinopathy (oximetry)³²^,⁶²^,⁷⁷^,⁸³^,⁸⁹ Fibulin 3 deficiency⁶⁹ Membranoproliferative glomerulonephritis type 2⁶⁹ Diabetic macular edema⁶⁸ Ischemic disease (RVO) (oximetry)⁸²
Ocular Findings in a Systemic Disease
Hyperbilirubinemia (oximetry)⁶⁶ AD⁵⁶^,⁶¹^,⁸¹ Diabetic ONL and reaction to erythropoietin or LCVS1001⁴³^–⁴⁵ AD and response to γ-GSH²⁷ Cerebral malaria (oximetry)⁷⁵

The listed phenomena could allegedly be differentiated from healthy individuals or were subject to oximetry alone (indicated). Animal studies are shown in italics.

ARM, age-related maculopathy; LCVS1001 and γ-GSH, compounds not otherwise specified; ONL, outer nuclear layer; RPE, retinal pigment; RVO, retinal vein occlusion.