Table 1.
Characteristics of patients with refractory celiac disease.
| Sex | Age (Y) | Age at CD diagnosis (Y) | Age at RCD diagnosis (Y) | RCD type | Duodenal histology | Aberrant IEL (%) | Immunological comorbidities | Other comorbidities | TCRγ | Compliance to GFD | Therapy | Covid-19 symptoms | Antiviral lifestyle |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| F | 63 | 49 | 50 | 2 | 3c | Unknown | SLE, autoimmune hepatitis, mycosis fungoides | Osteoporosis | Monoclonal | Optimal | Azathioprine Corticosteroids | No | Yes |
| F | 46 | 39 | 40 | 2 | 3b | 82 | Erythema nodosum | – | Monoclonal | Optimal | Budesonide | No | Yes |
| M | 56 | 44 | 48 | 1 | 3c | 10 | – | Arterial hypertension | Policlonal | Optimal | – | No | Yes |
| F | 63 | 61 | 64 | 1 | 3c | 0 | – | Osteoporosis | Policlonal | Optimal | – | No | Yes |
| F | 45 | 39 | 40 | 1 | 3b | 0 | Autoimmune thyroiditis, collagenosic colitic | – | Policlonal | Optimal | Budesonide | No | Yes |
| F | 77 | 70 | 73 | 1 | 3a | 0 | – | Osteoporosis | Policlonal | Optimal | Budesonide | No | Yes |
| F | 62 | 53 | 58 | 2 | 3b | 0 | – | HBV hepatitis, osteoporosis | Monoclonal | Optimal | Budesonide | No | Yes |
| M | 63 | 62 | 63 | 2 | 3c | 33 | Lymphocytic colitis | Thalassemic trait | Policlonal | Optimal | Budesonide | No | Yes |
| F | 30 | 26 | 28 | 1 | 3a | 0 | – | – | Policlonal | Optimal | – | No | Yes |
| F | 75 | 68 | 70 | 1 | 3a | 0 | Autoimmune hyperpara-thyroidism | Osteoporosis, rectal carcinoma | Policlonal | Optimal | – | No | Yes |
| F | 42 | 32 | 39 | 2 | 3c | 0 | – | – | Monoclonal | Optimal | Budesonide | No | Yes |
| M | 62 | 61 | 62 | 2 | 3c, UJ | 25 | Autoimmune thyroiditis | – | Policlonal | Optimal | Azathioprine | No | Yes |
| F | 66 | 62 | 63 | 2 | 3c, UJ | 60 | – | – | Monoclonal | Optimal | Budesonide cladribine | No | Yes |
| M | 77 | 64 | 69 | 2 | 3c | 85 | Purpura | Osteoporosis, HBV hepatitis | Monoclonal | Optimal | Budesonide cladribine | No | Yes |
| F | 53 | 46 | 48 | 1 | 3a | 0 | – | Asthma | Policlonal | Optimal | – | No | Yes |
| F | 69 | 50 | 68 | 2 | 3a | 44 | Collagenosic colitis | Osteoporosis | Monoclonal | Optimal | Budesonide | No | Yes |
| F | 51 | 51 | 53 | 2 | 3a | 0 | Osteoporosis | Policlonal | Optimal | – | No | Yes | |
| F | 76 | 76 | 80 | 2 | 3b | 81 | Autoimmune hepatitis | Osteoporosis, secondary hyperparathyroidism | Monoclonal | Optimal | Budesonide | No | Yes |
| M | 52 | 52 | 52 | 2 | 3c | 40 | – | – | Monoclonal | Optimal | Budesonide | No | Yes |
| F | 35 | 35 | 36 | 1 | 3c | 0 | – | Osteoporosis | Policlonal | Optimal | – | No | Yes |
| F | 36 | 36 | 38 | 1 | 3a | 40 | – | Osteoporosis | Monoclonal | Optimal | Budesonide | No | Yes |
UJ: ulcerative jejunoileitis. SLE: systemic lupus erythematosus. HBV: hepatitis B virus.