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. 2020 Aug 22;155(4):143–151. doi: 10.1016/j.medcle.2020.05.004

Table 2.

Meta-analysis of laboratory findings between severe and non-severe patients with COVID-19.

Parameters No. of cohort Sample size (Severe/Non-Severe) SMD 95% CI I2 (%) Statistical method p Publication bias (p Egger)
Leukocyte (×109/L) 24 1119/2825 0.35 0.09 to 0.61 90 REM 0.009* 0.725
Lymphocyte (×109/L) 24 1090/2832 −0.57 −0.73 to −0.40 73 REM <0.00001* 0.547
Neutrophil (×109/L) 16 675/1257 0.50 0.28 to 0.72 72 REM <0.0001* 0.892
Thrombocyte (×109/L) 15 624/2103 −0.33 −0.52 to −0.14 67 REM 0.0006* 0.840
D-dimer (μg/mL or mg/L) 14 451/1205 0.56 0.32 to 0.80 74 REM <0.00001* 0.865
CRP (mg/L) 17 737/1272 0.99 0.69 to 1.29 85 REM <0.00001* 0.112
PCT (ng/mL) 13 596/1041 0.19 −0.06 to 0.44 75 REM 0.14 0.930

SMD, standard mean difference; CI, confidence interval, FEM, fixed-effect model; REM, random-effect model.

*

p < 0.05.