Supplementary table 1.

Search history.

Search database	Search term	Results
PubMed	(sickle cell anemia) AND (((((voxelotor) OR (crizanlizumab)) OR (glutamine)) OR (GBT440)) OR (Seg101))	86
Clinicaltrials.gov	Voxelotor OR GBT440 AND sickle cell anemia = 13 Crizanlizumab OR Seg101 AND sickle cell anemia = 7 Glutamine AND sickle cell anemia = 5	25